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prozak and E
Former Member
Posts: 1,876,323 The Mix Honorary Guru
Some of my friends have decided that they want to discover the wonderful world of ecstasy, but one of them is currently on prozak, to counter some quite evere depression. Does anyone here know whether it might not be a good idea to take ecstasy whilst on prozak? I know they both work y altering the levels of serotonin released, so I thought there might be some kind of bad reaction, or maybe the prozak not actually working as a result of it. Can anyone advise?
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perhaps not such a good idea?
http://www.erowid.org/chemicals/mdma/mdma_info9.shtml.
Hope that clears up a few things. Bear in mind though that if your friend is severely depressed, the combination of NOT taking the Prozac and the increased serotonin levels caused by the MDMA could indeed make their depression worse...
You will have no chance what-so-ever to roll while on any SSRI's.
MDMA works by "tricking" the SERT's (Serotonin Transporters) to run backwards and actually pump serotonin into the synapse, where it then binds to a serotonin receptor and causes the neuron to fire.
Now, Prozac (and all SSRI's) work by occupying the SERT in order to keep as much serotonin in the synapse as possible.
The purpose of a SERT (when not on drugs) is to make sure there isn't too much serotonin in the synapse, so when the serotonin has binded to a receptor (and causing the neuron to fire) it will detach itself and then be transfered out of the synapse through the SERT and will then either make it back into the vesicle (where it came from) or destroyed by a chemical in the brain called MAO. (Mono Amine Oxidant).
So don't waste your money on extacy pills while on Prozac.
Extacy however stimulates the body to release excess amounts of serotonin.
Two different puppies
As others have said if they have been given a script for prozac then they probally shouldnt be using pills anyway.
I have heard some talk that prozac after taking pills can help with the neurotoxicity, however I'm not sure if its really based on evidence.