Growing out of your mates...

Hey I'm new to this thought I'd give it a go...I haven't been having a very terrific time at the moment...broke up with my boyfriend of 2 years, but i was on good terms, however it hasn't stopped me feeling like complete rubbish. What made it worse was my best friend at Uni a week later basically metaphorically slapped me in the face telling me we had drifted apart, which was news to me, but regardless we're not speaking anymore. Even worse I've fallen out with some friends from back home over the New Year, one especially is my longest mate from school. But we just have completely different lives now. I have the feeling that with my longest mate at least we just have nothing in common anymore and it sounds bad and everything she does just annoys and depresses me! I hate it but I can't ignore it and I can't keep putting up a front to her, it's not fiar on either of us...and I'm also scared because my friend pool seems to be shrinking by the day...I do have some good friends at Uni but I'm often alone in my flat a lot and I'm getting really down...missing my boyfriend, as someone to talk to as much for a hug, and I feel like I'm becoming more and more isolated all in the space of a month. Any voices of experience or advice on what to do next. Got my 3rd year exams in 2 weeks and my concentration is non-existent, any rays of hope would be much appreciated!