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Ecstasy, Seratonin, and You.

Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
Hiya <IMG SRC="smile.gif" border="0" ALT="icon">

This is one for the more long-term pill users really. I'm not trying to alienate the people just getting into it, but i doubt that they're familiar enough with what i'm going to talk about to comment. Feel free to prove me wrong however. <IMG SRC="smile.gif" border="0" ALT="icon">

Firstly, some background info. Been taking pills for roughly two and a half years now, and it's mostly been good. Started getting a bit silly with them after a while, but soon sorted myself out, and now, on average,i do them about once a month.

When i was caining it, and raving most weekends, i used to get really bad comedowns. The day after the night before ( <IMG SRC="wink.gif" border="0" ALT="icon"> ) i'd be OK, obviously still a bit flaky, but nothing major. For the rest of the week, until at least Thursday/Friday, i'd feel like absolute shite. Not just shite, to be honest, at times it got to the stage where i'd start crying for no real reason, the tears would just well up ( for reference, i'm a 20 year old bloke, who isn't prone to bouts of feminity <IMG SRC="wink.gif" border="0" ALT="icon"> )

This was part of the reason why i calmed it all down, as it was literally ruining my life. I was a mess.

Which puts me where i am now, a light user who has struck the magic balance, so it seems. Which brings me to the point of this post...

Having read a lot of different information sources about Ecstasy, there seems to be a bit of a grey area over what damage pills actually do to your brain. The most common one is that 'Regualar Ecstasy use will damage the Seratonin receptors of the human brain' (not a proper quote by the way).

I find myself wondering though, what they actually mean by 'damage'. Like i say, i don't really do many pills nowadays ( not by some of the standards set by some of you lot, anyway <IMG SRC="wink.gif" border="0" ALT="icon"> ).

Now, in the periods betweeen pills, i find that the comedown is hardly noticeable, and only tends to last for a day. For the following weeks though, things just seem to get better and better! I've spent some days walking around with an idiot grin on my face, all day, for no reason whatsoever.

Which has got me thinking; do any of you lot think it's possible that, after regular use, the Seratonin receptor thingys actually work 'better' than before? I don't know whether it's just the fact that i notice the difference between now and before more, (try saying that fast) or if, like i say, the wotsit's are churning out more Seratonin than they used to. Even before i took my first pill, i can never remember feeling so brilliant, so happy, without there actually being a cause for it.

It's not like i'm complaining, ( <IMG SRC="biggrin.gif" border="0" ALT="icon"> ) i just wanted to know if anyone else is experiencing anything similar.

Cheers for taking the time out to read this, i know i waffle on <IMG SRC="wink.gif" border="0" ALT="icon">

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    Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
    It causes the receptors to bridge over and over-release seritone which in turn damages them and they grow back differently, deformed...

    I'd hardly see that as growing back better, but there is no proof of brain damage, neron-receptors can aledgedly fix themselves until after the age of 25, this of course is on light useage.

    The levels of seritone in your brain are depleated down to a maximum of about 40%, thats why you find you can keep getting the effects (you'd mostly feel the speed in the pills) and this takes up to 2 weeks to replenish back to the brains natural storage, heavy and regular use can't be good.

    I used to be a heavy user, been taking pills since I was 14, so about 6 years now, taking 7 a night, twice a week and my diet and health suffered really badly, I found I couldn't concentrate properly.. I was going down hill pretty harsh..

    So I moved to NZ and cause of costs and things my health is back to normal and I don't take pills quite as much, I don't find I get the comedowns like I used to and I can focus on the daily task as normal... <IMG SRC="smile.gif" border="0" ALT="icon">

    Hope that sheds some light!

    [ 08-05-2002: Message edited by: Justin Credible ]
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    Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
    My magic formula (which seems to be working for me) is not to take more than 1. If i want a stronger effect i taylor my pill-time activities to suit (dancing instead of sitting etc).
    I know this may seem a little pointless to some on the group, and you could well be right if you're used to taking 5+. But i have never been in the habit of throwing lil' friends down my throat, the most i've taken in 1 night is 3, and that was only once.

    This seems to work for me, keeping me relativly chilled through-out the week. The only thing that piss's me off is my mates going through emotional junk / depression / mood swings monday - thursday.
    Fortunatly i have lots of activities that don't really involve my main group of mates (the druggy ones anyway) so io can ignore it <IMG SRC="smile.gif" border="0" ALT="icon">
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    Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
    When I drop, I usually drop 2...1 then another 1 later in the nite...I sometimes drop 3...double drop, then 1 later...the most I've had in 1 nite was 4...my comedown seemeed to be worse, but I didn't really notice it....I never really do <IMG SRC="biggrin.gif" border="0" ALT="icon"> <IMG SRC="biggrin.gif" border="0" ALT="icon">
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    Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
    I used to average 3, but at the moment have cut down to 2 (exams and stuff). Last summer, when I was going through my clubbing honeymoon, I ddin't get any comedown at all, I got the opposite if anything, and would feel great for a few days.

    This last weekend I took 5 across 2 nights, and didn't get a comedown in the slightest, I imagine because I had such a fucking good time that I could ignore it!

    Comedowns in general rarely effect me much past monday, maybe tuesday. I don't get grumpy or pissed off ect, just physically knackered, and mentally blurred.

    I do sometimes get that thing when, having not taken pills recently, I'm walking down the street, or sitting at home, and I get this sudden burst of euphoria... I don't know why, but I like it. I find generally I'm a happy person, and I don't let the comedowns get to me. Occasionally I get bursts of depression/paranoia or something like that, and I'm not sure whether to blame it on my weird seretonin levels or a relapse of the depression I used to suffer from. Or both.

    I know people who have become depressed, and blame it on pills. At the same time I know people who have taken pills for a lot longer, and feel fine. It must depend largely on the person, and I watch my own situation carefully.
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    Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
    Kioka, I don't think that your seratonin level will be higher than it was before I think it's because you've clamped down to once a month and it's stopped messing the levels about as much.
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    Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
    I think that will have alot to do with the really bad experiences you had in the past. I'd like to know what happens to seratonin in non pill users. The way I see it, it's either your liver or your seratonin! Russian roulette eh! I don't know how widely known it is, but I use 5-HTP every day, 2 after pills and that has helped alot. Has anyone else tried these?
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    Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
    I thinkg that the pill should have a manual how to use it to avoid depression and being fucked the another day or week. I assume that you all well know www.erowid.org and most important is to do research and to read about who other think and recommend. Maximum 2-3 pill a night once a week or better once montht will keep you with brilliant spirit. Longer standstill will be appreciated. Important is chill-out during exercises and instead of taking another pill shortly after the first one (this is waste of material really) you should involve in some sort of pleasurable fun and interraction with others to get the emotions and to get the love feeling and understanding for others. I tried to take pills dayly and it is possible but i did not get the most and got used to do it and somehow it was normal to take pill in the morning or to take it at work and at home when my girfriend was looking for my red eyes but she saw just big eyes but she did not know. She wants me to stop my drug hobby. And i was even smoked yesterday but she does not know cause i am liar. But i just want her to be tolerant.
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    Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
    it was normal to take pill in the morning or to take it at work

    Let's get this straight, you were taking gary's at work?

    [ 09-05-2002: Message edited by: Andy_Booth ]
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    Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
    I started doing pills when I was 14 and just got into the rave scene ...and since then have been a regular user of pills.

    A the moment I do pills every other weekend, it's still too much, and I need to cut down but it's nothing compared to how I used to use them. I used to do 15+ some nights and then carry on dropping them into the next day, while drinking up the pub. This only went on for a couple of months before I decided to sort myself out. I think a lot of people go through a stage like that, only to calm down when they realise that they're going a bit OTT.

    There's no denying it, ecstasy has changed me, but mostly for the better I think. I'm definately a more tolerant and understanding person than I was before, and it's given me some of the best nights of my life.

    Do I regret it?


    ...do I fuck! <IMG SRC="biggrin.gif" border="0" ALT="icon">
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    Former MemberFormer Member Posts: 1,876,323 The Mix Honorary Guru
    Originally posted by Andy_Booth:
    <STRONG>

    Let's get this straight, you were taking gary's at work?

    [ 09-05-2002: Message edited by: Andy_Booth ]</STRONG>

    Yes, i was driving firm car and i had same pills at home so i managed to get home take the ecstasy and drive to visit the customer to repar the non-working terminal than to cessate some modem, buy some tickets for my boss and believe me that i am making it harder for me to work on a pill. When i have pill a have to take them right now.
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